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SCI

6May

TherapeutictargetingofATRyieldsdurableregressionsinsmallcelllungcancerswithhighreplicationstress

ThomasAnish,TakahashiNobuyuki,RajapakseVinodhNetal.TherapeutictargetingofATRyieldsdurableregressionsinsmallcelllungcancerswithhighreplicationstress.[J].CancerCell,,39:-.e7.

Smallcellneuroendocrinecancers(SCNCs)arerecalcitrantcancersarisingfromdiverseprimarysitesthatlackeffectivetreatments.

小细胞神经内分泌癌（SCNC）是多种原发部位引起顽固性癌症，缺乏有效治疗方法的。

Usingchemicalgeneticscreens,weidentifiedinhibitionofataxiatelangiectasiaandrad3related(ATR),theprimaryactivatorofthereplicationstressresponse,andtopoisomeraseI(TOP1),nuclearenzymethatsuppressesgenomicinstability,assynergisticallycytotoxicinsmallcelllungcancer(SCLC).

使用化学遗传学筛选，我们发现共济失调毛细血管扩张症和rad3相关（ATR）是复制应激反应的主要激活因子，拓扑异构酶I（TOP1）是抑制基因组不稳定性的核酶，在小细胞肺癌中具有协同细胞毒性作用（SCLC）。

Inaproof-of-conceptstudy,we